Awesome. I like your take on madness, and the RPG theme was especially interesting.
To be honest with you though, I think there are quite a number of flaws, such as the plot. Most of the parts were almost unnecessary , considering that most of the characters are slightly overpowered, and the boss fight, well, it was kind of disappointing as I was hoping of some sort of badass RPG style beatdown. The animation itself was pretty fluid, although I do have to remind you that people don't usually just stand there while watching you load your weapon (or spells,whatever xD)
Nevertheless, there are quite a few things that make this animation worth watching.The music, for example, was well synced. The custom sprites made it a lot more interesting, and i can see that you've put a lot of effort in the spell-casting animations. The "conversations", along with a few parts of the animations were simple, yet they boosted the humor factor and was a huge plus.
Overall, although it wasn't the best animation I've seen so far, the effort you put in was definitely worth the five stars,and I hope to see more from you in the future. :D